ESR7: Application of glycosyltransferases to functionalise protocells

Location: CERMAV-CNRS, FR

Supervisor Prof Christelle Breton

The research relies on the use of glycosyltransferases (GTs) to expand the tool box of synthetic glycobiology methods. GTs are the key enzymes that synthesize the complex glycans that are found on glycoconjugates (i.e. glycolipids and glycoproteins). Therefore, they present a great interest in the context of the SynBioCarb project for building a sophisticated glycolandscape on the surface of artificial cells or tissues with applications in tissue engineering, drug delivery and diagnostics. This opens the possibility to add one or several sugars at specific position(s) of a glycan or to introduce unnatural sugars that could serve for biorthogonal chemistry. A small set of GTs, with specificities related to glycans selected by the consortium, will be produced in recombinant forms and functionally characterized and/or engineered to be adapted to the needs of the project.

Applicants should meet the following eligibility criteria:

  • Have a Diploma and/or a Master Degree in Biochemistry or Structural Biology.
  • Have less than 4 years research experience at the signature of the contract (measured from the time the Master’s degree has been obtained).
  • Not have a PhD already.
  • Not have resided or carried out main activity in France for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
  • Excellent knowledge of the English language (spoken and written / proficiency level)

The ESR will be contractually employed by CNRS and will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Skłodowska-Curie Actions-ITN general conditions.

Candidates should submit a CV, cover letter and the names and contact details of at least 3 references via the online application page

Informal enquiries can be made by e-mail to christelle.breton@cermav.cnrs.fr and anne.imberty@cermav.cnrs.fr indicating reference synBIOcarb_ESR7 in the subject.

The deadline for applications is 07/01/2019 

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