ESR6: Engineering of neo-lectins and janus lectins

Location: CERMAV-CNRS, FR

Supervisor: Dr Anne Imberty

The research will involve the engineering of lectins in order to control their architectures, valency  and binding sites.  Novel lectins will be constructed by fusing β-propeller domains to carbohydrate-binding modules with different specificities. The neo-lectins and janus lectins will be characterized by biophysical methods (x-ray crystallography, SAXS, microcalorimetry, surface plasmon resonance). They will be adapted to the need of the other teams, as tools to characterize the surface of cells and of vesicles, or to associate them by cross-linking.

Applicants should meet the following eligibility criteria:

  • Have a Diploma and/or a Master Degree in Biochemistry or Structural Biology.
  • Have less than 4 years research experience at the signature of the contract (measured from the time the Master’s degree has been obtained).
  • Not have a PhD already.
  • Not have resided or carried out main activity in France for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
  • Excellent knowledge of the English language (spoken and written / proficiency level)

The ESR will be contractually employed by CNRS and will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Skłodowska-Curie Actions-ITN general conditions. 

Application procedure:

Candidates should submit a CV, cover letter and the names and contact details of at least 3 references via the online application page

Informal enquiries can be made by e-mail to Anne.imberty@cermav.cnrs.fr indicating reference synBIOcarb_ESR6 in the subject.

The deadline for application is 07/01/2019

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