Development of a lectin kit for quality control of recombinant glycoprotein
This research will involve the development of a lectin chip covering the detection of the major undesirable glycan structures in therapeutic glycoproteins to allow real-time monitoring and control. We will clone, express and purify several lectins that have been reported in the literature to present a specificity towards glycan epitopes that may rise to unwanted immune responses in the production of glycosylated biopharmaceuticals. Technology for biosensors will be investigated with partners.
Supervisor Dr Ludovic Landemarre